The causes, pace and magnitude of deforestation and forest degradation have changed over time. The way that different causes of deforestation link together and the effects they have on forests varies across regions. Globally, a multitude of approaches have been implemented to halt deforestation and forest degradation. While progress has been made in halting forest loss and degradation, both continue at alarming rates. This report provides a comprehensive analysis of deforestation connecting drivers and responses globally by taking a closer look at 24 “deforestation fronts” – places that have a significant concentration of deforestation hotspots and where large areas of remaining forests are under threat. Over 43 million hectares were lost in these fronts between 2004 and 2017, an area roughly the size of Morocco. The analysis presented here focuses on the tropics and sub-tropics, which accounted for at least two-thirds of global forest cover loss from 2000 to 2018 and where forest fragmentation is significant. Nearly half of the standing forests in these 24 deforestation fronts have suffered some type of fragmentation. Deforestation tends to oscillate over time. Recent trends indicate that deforestation will persist in these fronts unless there is collective action and more integrated approaches tailored to each front. To be more effective, the different responses to halt deforestation and forest degradation have to reinforce each other.