Around the world, territory-wide coalitions are forming among local resource users from all sectors. They define and pursue a shared vision and strategy for regeneration and work to resolve trade-offs and find synergies. This integrated landscape approach has been endorsed by the UN’s conventions on climate change, biodiversity, and land degradation and by the High-Level Political Forum on Sustainable Development, the UN Food System Summit, and UN-Habitat. We have learned much and developed practical tools to organize, design, and finance integrated landscape initiatives to secure a better future for people and nature. But few countries have national policies that support these Landscape and Seascape Partnerships, even though providing that enabling environment is critical. Fortunately, models have emerged from experiences worldwide that demonstrate it’s possible to align national policies, programs, and financial flows with local partnerships’ action plans. This White Paper pulls this evidence together to show how national governments can craft a policy framework that fits their priorities and institutional context.